Amide derivatives
US4636505A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 15, 1983 |
| Grant date | Jan 13, 1987 |
| Priority date | — |
| Expiry date | Jul 15, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/62
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Acylanilides of the formula ##STR1## wherein R.sup.1 and R.sup.2, the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; PA0 R.sup.3 is hydrogen or halogen; PA0 R.sup.4 is hydrogen or alkyl, or is joined to R.sup.5 ; PA0 R.sup.5 is hydrogen, hydroxy, alkoxy or acyloxy or is joined to R.sup.4 ; PA0 R.sup.6 is alkyl or halogenoalkyl, or has the formula --A.sup.3 --R.sup.8 or --A.sup.4 --X.sup.2 --A.sup.5 --R.sup.9 ; PA0 A.sup.1 and A.sup.4, the same or different, each is alkylene; PA0 A.sup.2, A.sup.3 and A.sup.5, the same or different, each is a direct link or alkylene; PA0 X.sup.1 and X.sup.2, the same or different, each is oxygen, sulphur, sulphinyl, sulphonyl, imino or alkylimino; PA0 R.sup.7 and R.sup.9, the same or different, each is alkyl, alkenyl, hydroxyalkyl, cycloalkyl, phenyl optionally substituted, naphthyl or heterocyclic optionally substituted; PA0 and R.sup.8 is phenyl, naphthyl or heterocyclic as defined above for R.sup.7 or R.sup.9 ; processes for their manufacture and pharmaceutical compositions containing them. The acylanilides possess antiandrogenic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.