2,3,4-trinor-1,5-inter-meta-phenylene-prostacyclin compounds useful in inhibiting thrombocyte aggregation
US4638002A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 30, 1983 |
| Grant date | Jan 20, 1987 |
| Priority date | — |
| Expiry date | Dec 30, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5456
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new 2,3,4-trinor-1,5-inter-m-phenylene-PGI.sub.2 derivatives of the formula (I) ##STR1## wherein A stands for carboxy, cyano, tetrazolyl or --COOR.sup.3 or --CONR.sup.1 R.sup.2 ; PA1 R.sup.3 is C.sub.1-4 alkyl or an equivalent of a pharmacologically acceptable cation: PA1 R.sup.1 and R.sup.2 each stands for hydrogen, phenyl; C.sub.1-5 alkyl, optionally substituted by carboxy, hydroxy, phenyl or C.sub.2-5 alkoxycarbonyl; or C.sub.1-4 alkylsulfonyl; or PA1 R.sup.1 and R.sup.2 together form an .alpha.,.omega.-alkylene chain containing 3-6 carbon atoms; PA1 B stands for oxygen or methylene; PA1 Y is optionally bromo-substituted vinylene or a --C.tbd.C-- group: PA1 R.sup.4 stands for hydrogen or tetrahydro-pyran-2-yl; PA1 R.sup.5 represents an alkyl group containing 5-9 carbon atoms, which can be optionally interrupted by one or more oxygen atom(s) or --CH.dbd.CH-- or --C.tbd.C-- group(s) and/or optionally substituted by halogen; or a phenyoxymethyl group optionally substituted by halogen or trifluoromethyl; or an alkenoyloxymethyl group containing 3-5 carbon atoms; PA1 R.sup.6 is hydrogen or C.sub.1-4 alkyl; PA1 R.sup.7 stands for hydrogen, halogen, cyano, C.su…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.