Thrombin-binding substance and process for its production
US4638050A · kind A · utility
8Cited by
3References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 20, 1985 |
| Grant date | Jan 20, 1987 |
| Priority date | — |
| Expiry date | Mar 20, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/851
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A thrombin-binding substance derived from human tissue and having the characteristics of (a) molecular weight: 88,000.+-.20,000 in reduced condition and 71,000.+-.20,000 in unreduced condition; (b) isoelectric point: .sub.p H 4.2.+-.0.5; (c) affinity: strong for thrombin; (d) activities: capable of promoting the thrombin-catalyzed activation of protein C and prolonging clotting time; and (e) stability: stable over a .sub.p H range of 2 to 10 and stable to denaturing agents (sodium dodecylsulfate and urea) and to a pepsin treatment, is effectively useful for thrombolysis and anticoagulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.