Process for the preparation of insulin derivatives
US4639332A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 1, 1984 |
| Grant date | Jan 27, 1987 |
| Priority date | — |
| Expiry date | Aug 1, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/26
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of insulin derivatives of the formula I ##STR1## in which R.sup.30 represents the radical of a neutral L-amino acid which can be genetically coded, X represents identical or different radicals of L-amino acids which can be genetically coded, at least one of which is a basic amino acid, it being possible for the C-terminal member to be homoserine-lactone, Y denotes Phe or H and n denotes 1, 2 or 3, by splitting of intermediates, proinsulin, preproinsulin or analogs thereof, which comprises carrying out the splitting reaction close to the isoelectric point of the insulin derivatives of the formula I in the presence of an aromatic hydroxy compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.