Patent · US Expired

Process for converting preproinsulin analogs into insulins

US4639333A · kind A · utility

4Cited by

0References

16Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Rainer Obermeier
Rolf Geiger · Frankfurt am Main, DE
Ulrich Grau · Emskirchen, DE

Key dates

Filing date	Oct 12, 1984
Grant date	Jan 27, 1987
Priority date	—
Expiry date	Oct 12, 2004

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S930/26
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of insulins from analogs of preproinsulins, which comprises reacting preproinsulin analogs, at a pH below the isoelectric point of the insulins in the presence of trypsin or a trypsin-like endopeptidase, with an ester of natural amino acids or their derivatives and then cleaving off the ester group and other protective groups which may optionally be present.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.