Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood products

US4640834A · kind A · utility

Assignee

• Immuno Aktiengesellschaft fur chemisch-medizinische Produkte · AT

Inventors

• Johann Eibl · Wien, AT
• Otto Schwarz · Waldshut-Tiengen, DE
• Fritz Elsinger · Wien, AT
• Gunter Wober · Oberwaltersdorf, AT
• Anton Philapitsch · Staprijk, AT
• Yendra Linnau · Wien, AT
• Friedrich Dorner · Wien, AT
• Karl Trambauer · Wien, AT
• Wolfgang Frechinger · Wien, AT

Key dates

• Filing date: Feb 26, 1985
• Grant date: Feb 3, 1987
• Expiry date: Feb 26, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of inactivating viruses in blood products is described, wherein the blood products are heat-treated in a humid or in a solid state in the presence of inorganic or organic hydroxyl group-containing compounds having an H.sup.+ -dissociation constant of <10.sup.-11 in a concentration of more than 0.05 (5% by weight) and less than 0.70 (70% by weight). The hydroxyl group-containing compounds may be water, methanol, ethanol or mannitol. The temperature may amount up to 121.degree. C., the heat treatment may last from 1 s to 100 h. The inactivation method may be applied for producing blood products selected from enzymes, proenzymes including coagulation factors, enzyme inhibitors, immunoglobulins, albumin, plasminogen, fibrinogen, fibronectin or plasma, the inactivation destroying any reproducible filterable pathogens that might be present.