Method and system for detection of complement pathway activation
US4642284A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1983 |
| Grant date | Feb 10, 1987 |
| Priority date | — |
| Expiry date | Jun 13, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and system for detecting and preferably measuring the presence of an activated complement complex in a sample is discussed. The presence of such an activated complex is indicative of complement pathway activation and includes a first complement component and a second complement component. The method uses a first binding agent specific to the first complement component and a second binding agent specific to the second complement component which when bound with the complex forms an aggregate. The second specific binding agent includes a label whose presence is used to detect and measure the amount of aggregate and therefore activated complex in a sample. An assay system and aggregate for use in an assay system are also discussed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.