Process for the production of .beta.-carbolines by dehydrogenation

US4644062A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gregor Haffer · Berlin, DE
• Helmut Borner · Berlin, DE
• Andreas Huth · Berlin, DE

Key dates

• Filing date: Feb 3, 1986
• Grant date: Feb 17, 1987
• Expiry date: Feb 3, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

.beta.-carbolines of formula I ##STR1## wherein R=C.sub.1-5 alkyl PA0 R.sup.4 =H, C.sub.1-5 alkyl or --(CH.sub.2).sub.n --OR with n=1 or 2 and PA0 R.sup.A =H, R, (CHR).sub.n --OR, OCH.sub.2 Ph, OPh, OPh(Cl,Br),OR,OCH.sub.2 Ph(Cl,Br) NRR, Cl or Br, wherein n and R have the above meanings and there are one or two R.sup.A 's are prepared, by dehydrogenation at reaction temperatures below ambient temperature in an inert solvent with tert-butyl hypochlorite and a tertiary amine.