Diphosphonic acid derivatives and pharmaceutical preparations containing same

US4645762A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Clemens Rufer
• Irmgard Boettcher · Lahr (Eifel), DE

Key dates

• Filing date: Jul 5, 1983
• Grant date: Feb 24, 1987
• Expiry date: Jul 5, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/4025
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Diphosphonic acid derivatives of the formula ##STR1## wherein X is cyano, 2-cyanoethyl, or 3- aminopropyl and Y is H, or X and Y together represent dimethylaminomethylene ((CH.sub.3).sub.2 NCH.dbd.), and PA1 R is hydrogen, alkyl of 1-4 carbon atoms, or a cation derived from a base, especially an alkali metal atom, PA1 excluding the cyanomethanebis (phosphonic acid diethyl ester), PA1 are pharmacologically active compounds.