Patent · US Expired

Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit

US4645854A · kind A · utility

12Cited by

2References

4Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Thomas R. Verhoeven · Cranford, US
James M. McNamara · Rahway, US
Meyer Sletzinger · North Plainfield, US

Key dates

Filing date	Apr 25, 1985
Grant date	Feb 24, 1987
Priority date	—
Expiry date	Apr 25, 2005

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C69/732
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A stereoselective process for the preparation of antihypercholesterolemic agents of the HMG-CoA reductase inhibitor type comprises treatment of an intermediate .beta.-hydroxyketone with a trialkylborane and sodium borohydride at low temperatures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.