Process for obtaining ready for fertilization sexual products from sexually mature fish

US4647552A · kind A · utility

Assignee

• Kozponti Valto-es Hitelbank Rt., Innovacios Alap · HU

Inventors

• Tamas Gulyas · Szekszárd, HU
• Aniko Horvath · Budapest, HU
• Gyorgy Keri · Budapest, HU
• Karoly Nikolics · Budapest, HU
• Balazs Szoke · Budapest, HU
• Istvan Teplan · Budapest, HU

Key dates

• Filing date: Dec 20, 1984
• Grant date: Mar 3, 1987
• Expiry date: Dec 20, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a process for obtaining ready-for-fertilization sexual products from sexually mature fish in a period independent of their natural spawning season, in which actual stage of ripening is determined by probing of sexual products [sperm or eggs], fish not yet ripe for ovulation are separated from ripe fish, compounds of hormonal effect are administered to fish, and after the ovulation sexual products are obtained from the fish or from their environment. In the process according to the invention a nonapeptide-C.sub.1-4 -alkyl-amide or a decapeptide amide of the general formula (I), EQU Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4 (I) wherein PA0 X.sub.1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group, PA0 X.sub.2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group, PA0 X.sub.3 represents an L-amino acid group having a C.sub.1-4 alkyl or C.sub.2-4 alkyl-amide side chain, PA0 X.sub.4 is a glycine-amide or a C.sub.1-4 alkyl-amide group, as well as salts or metal-complexes of these compounds are administered to fish in a dose of 0.1 .mu.g to 5 mg, and to fish …