Gonadoliberin derivatives and process for the preparation thereof

US4647553A · kind A · utility

Assignee

• Innovacios Alap Kozponti Valto Es Hitelbank RT. · HU

Inventors

• Tamas Gulyas · Szekszárd, HU
• Aniko Horvath · Budapest, HU
• Gyorgy Keri · Budapest, HU
• Karoly Nikolics · Budapest, HU
• Balazs Szoke · Budapest, HU
• Istvan Teplan · Budapest, HU

Key dates

• Filing date: Dec 20, 1984
• Grant date: Mar 3, 1987
• Expiry date: Dec 20, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to gonadoliberin derivatives of the general formula (I) EQU Glp--His--Trp--Ser--Tyr--X.sub.1 --X.sub.2 --X.sub.3 --Pro--X.sub.4 wherein PA0 X.sub.1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group, PA0 X.sub.2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group, PA0 X.sub.3 represents an L-amino acid group having a C.sub.1-4 alkyl or C.sub.2-4 alkanoyl-amide side chain, and PA0 X.sub.4 is a glycine amide or a C.sub.1-4 alkyl amide group, with the proviso that if X.sub.1 stands for a group other than glycyl and X.sub.2 is a tryptophyl group then X.sub.3 may not be leucyl, and the addition salts formed with therapeutically useable acids and complexes thereof. Furthermore the invention relates to a process for preparing these compounds. The new gonadoliberin derivatives can be effectively used for the reproduction process of fish, birds and mammals.