Oxygen permeable membrane in fermenter for oxygen enrichment of broth

US4649114A · kind A · utility

Assignee

• Intermedicat GmbH · CH

Inventors

• Herbert G. Miltenburger · Darmstadt, DE
• Sigfried Hessberg · Homberg (Efze), DE

Key dates

• Filing date: Dec 3, 1982
• Grant date: Mar 10, 1987
• Expiry date: Dec 3, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12M23/24
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The growth of animal cells in a fermenter is promoted by enriching the liquid nutrient medium or broth with oxygen diffused into the liquid through a permeable membrane, such as one made of silicone rubber or polytetrafluoroethylene (Teflon). Superior cell growth in larger volumes is achieved by feeding in the oxygen in this way instead of bubbling it in.