Process for the manufacture of novel benzazole derivatives, pharmaceutical preparations containing these derivatives, and their use
US4649149A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 1985 |
| Grant date | Mar 10, 1987 |
| Priority date | — |
| Expiry date | Jan 17, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R.sub.1 represents an optionally 4-substituted piperazino group or a group of the formula R.sub.2 --alk--X.sub.2 --, PA1 R.sub.2 represents optionally esterified carboxy or represents hydroxymethyl, PA1 alk represents lower alkylene or lower alkylidene, PA1 X.sub.1 and X.sub.2, independently of one another, each represents oxygen or sulphur, PA1 Ph represents 1,2-phenylene optionally substituted as well as by the group R.sub.1 --C(.dbd.X.sub.1)--NH--, PA1 X.sub.3 represents oxygen, sulphur or optionally substituted imino, and PA1 R.sub.3 represents optionally fluorine-substituted lower alkyl or cycloalkyl, and their salts. The compounds of the formula I, which have proved to be excellent micro- and macrofilaricides and schistosomacides, are manufactured according to methods known per se.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.