Substituted pyrroles with opioid receptor activity
US4649200A · kind A · utility
45Cited by
0References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 8, 1986 |
| Grant date | Mar 10, 1987 |
| Priority date | — |
| Expiry date | May 8, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted pyrroles of the formula: ##STR1## are disclosed wherein R.sup.1 is (C.sub.1 -C.sub.5)alkyl, C.sub.3 -C.sub.6 (cycloalkyl) alkyl, C.sub.5 -C.sub.7 (cycloalkenyl)alkyl, aryl, aralkyl, trans-(C.sub.4 -C.sub.5) alkenyl, allyl or furan-2-ylalkyl; R.sup.2 is H or OH, R.sup.3 is H, (C.sub.1 -C.sub.5)alkyl or (C.sub.1 -C.sub.5)alkanoyl and R.sup.4 is H or (C.sub.1 -C.sub.5) alkyl; as well as the pharmaceutically-acceptable salts thereof. These compounds are useful as analgesics and/or as selective kappa-opioid antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.