Aliphatic thioethers

US4649215A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Andreas von Sprecher · Oberwil, CH
• Ivan Ernest · Birsfelden, CH
• Alan J. Main · Far Hills, US
• Andreas Beck · Glückstadt, DE

Key dates

• Filing date: Jun 25, 1985
• Grant date: Mar 10, 1987
• Expiry date: Jun 25, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel asymmetric thioethers of the formula ##STR1## in which R.sup.1 represents a C.sub.1-3 -alkyl radical or a C.sub.1-3 -hydroxyalkyl radical of which the hydroxy group may be in esterified form, PA1 R.sup.2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms, PA1 R.sup.3 represents hydroxy, alkoxy or an optionally substituted amino group, and PA1 -X- represents a single bond, a methylene group or an optionally N-acylated primary aminomethylene group wherein the O-atom of the hydroxy group is in the transconfiguration relative to the S-atom, are effective as leucotriene-antagonists since they eliminate the contractions of smooth muscles caused by leucotrienes and are therefore suitable for the treatment of allergic, especially asthmatic, conditions.