Hemoglobin compounds
US4650786A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 19, 1984 |
| Grant date | Mar 17, 1987 |
| Priority date | — |
| Expiry date | Oct 19, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0021
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
There is described a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula I, EQU (PS)--X--(HB)--Z I where PA1 PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000, PA1 X represents a covalently bonded chemical bridging group, PA1 HB represents a hemoglobin residue, and PA1 Z represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups. There is also described hemoglobin linked to an oxygen affinity reducing ligand derived from inositol phosphate, and polymers of such linked hemoglobin. Processes for making the compounds, and their formulation and use as oxygen transporting agents, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.