Ethenylphenol-indoles having antiarythmic utility

US4650811A · kind A · utility

Assignee

• Roussel Uclaf · FR

Inventors

• Jacques Guillaume · Sevran, FR
• Francois Clemence · Paris, FR
• Neil Brown · Bergheim, DE

Key dates

• Filing date: Jan 14, 1985
• Grant date: Mar 17, 1987
• Expiry date: Jan 14, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel ethenylphenol indoles of the formula ##STR1## wherein R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, methylthio, --CF.sub.3, --NH.sub.2 and --NO.sub.2 or R and R.sub.1 together with the nitrogen atom form an optionally unsaturated heterocycle optionally containing a second heteroatom selected from the group consisting of --O--, --S-- and ##STR2## R' is hydrogen or alkyl of 1 to 5 carbon atoms, a together with X is .dbd.0 and b is hydrogen or a together with b is a carbon-carbon bond and X is hydrogen, the dotted line indicates the possibility of a double bond with the compounds having the trans configuration if a double bond, A is selected from the group consisting of ##STR3## and --(CH.sub.2).sub.n --, n is 2,3,4 or 5, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms with the proviso that R and R.sub.1 are not both hydrogen when A is ##STR4## and their non…