Aminoalkyl substituted urea derivatives and method of treatment
US4650900A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 30, 1985 |
| Grant date | Mar 17, 1987 |
| Priority date | — |
| Expiry date | Dec 30, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C275/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel amino alkyl substituted urea derivatives as well as their acid addition salts with pharmaceutically acceptable acids, to methods for the preparation of said derivatives and pharmaceutical compositions containing same, and a method for the treatment of tumors therewith. The novel urea derivatives have shown pronounced anti-neoplastic activity when tested against various tumor models in animals. The novel compounds of the present invention may be represented by the following formula: ##STR1## wherein X and Y are the same or different and are selected from the group consisting of a phenyl group, each of said phenyl groups being optionally substituted with one or two groups selected from halogen, CF.sub.3, OH, or alkoxy (1-4 C-atoms); and R.sup.1 and R.sup.2 are the same or different, and are each selected from the group consisting of lower alkyl groups having from one to four carbon atoms inclusive, or they form together with the nitrogen atom a saturated five- or six-membered heterocyclic ring; R.sup.3 and R.sup.4 are each selected from hydrogen, lower alkyl or alkenyl groups with from 1-6 carbon atoms inclusive, cyclopentyl or cyclohexyl; and n…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.