Encapsulating biological active substances into erythrocytes
US4652449A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Oct 27, 1983 |
| Grant date | Mar 24, 1987 |
| Priority date | — |
| Expiry date | Oct 27, 2003 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2313/243
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a process for the encapsulation in human or animal erythrocytes of at least one substance having a biological activity, characterized in that the primary compartment of at least one dialysis element is continuously supplied with an aqueous suspension of erythrocytes, the secondary compartment of the dialysis element contains an aqueous solution which is hypotonic with respect to the erythrocyte suspension in order to lyse the erythrocytes, the erythrocyte lysate is in contact with said substance having a biological activity and, in order to reseal the membrane of the erythrocytes, the osmotic and/or oncotic pressure of the erythrocyte lysate is increased after it has been brought into contact with said substance having a biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.