Patent · US Expired

Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin

US4652548A · kind A · utility

14Cited by

1References

17Claims

0Family size

Assignee

ELI LILLY AND COMPANY · US

Inventors

Ronald E. Chance · Westfield, US
Bruce H. Frank · Indianapolis, US
John A. Galloway · Cambridge, US

Key dates

Filing date	Dec 17, 1984
Grant date	Mar 24, 1987
Priority date	—
Expiry date	Dec 17, 2004

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/28
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A pharmaceutical composition which comprises, in association with a pharmaceutically acceptable carrier, human insulin, human C-peptide, and human proinsulin, said human C-peptide being present in a molar ratio, human insulin to human C-peptide, of from about 1:4 to about 4:1, and said human proinsulin being present in a weight ratio, human insulin to human proinsulin, of from about 1:100 to about 100:1, is useful in treating diabetics and in promoting attainment of natural hormonal homeostasis, thereby preventing or substantially diminishing or retarding diabetic complications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.