Quinoline derivatives and pharmaceutical compositions
US4652562A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 4, 1986 |
| Grant date | Mar 24, 1987 |
| Priority date | — |
| Expiry date | Jun 4, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy; PA1 n is an integer of 1, 2 or 3; PA1 R.sup.1 represents hydrogen and PA1 R.sup.2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, ##STR2## wherein Z stands for --O--, --S--, --NH-- or --N(lower alkyl)--; the dotted lines represent optional bonds; and PA2 m is 0 or 1; or PA1 R.sup.1 and R.sup.2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted), and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.