Preparation for percutaneous administration
US4654209A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 14, 1985 |
| Grant date | Mar 31, 1987 |
| Priority date | — |
| Expiry date | Aug 14, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/21
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.