Quaternary ammonium complexes of heparin
US4654327A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 3, 1985 |
| Grant date | Mar 31, 1987 |
| Priority date | — |
| Expiry date | Dec 3, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0075
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R.sup.1 and R.sup.2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms; and PA1 R, R' and R" are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms, ##STR2## where R.sup.1, R.sup.2 and R" are as defined above, ##STR3## where R.sup.3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms; and R.sup.1, R.sup.2, R.sup.3 and R and R' have the meanings given above; and ##STR4## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound. The compound thus formed has a structural formula selected from the group consisting of ##STR5## where R and R' are the same or different and are saturated or unsaturated aliphatic containing at least 10 carbon atoms; and ##STR6##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.