Pharmaceutical compositions for treating ulcers containing 2-aryltetraazaindenes

US4654344A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Michael Kloft · Weiterstadt, DE
• Hanns Wurziger · Darmstadt, DE
• Juergen Harting · Darmstadt, DE
• Hans-Joachim Enenkel · Darmstadt, DE
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Hans-Jochen Schliep · Traisa, DE

Key dates

• Filing date: Dec 20, 1985
• Grant date: Mar 31, 1987
• Expiry date: Dec 20, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C65/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --N.dbd.CH--CN.dbd.N-- or --CH.dbd.N--N.dbd.CH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto, dialkylamino, trifluoromethyl and/or --Z--R groups, Z is --O--, --S-- or --SO-- and R is alkyl, alkenyl, alkynyl or cyanomethyl, the alkyl, alkenyl and alkynyl groups each having up to 5 C atoms, and their physiologically acceptable salts, exhibit blood pressure, myocardial contraction, and anti-ulcer activities.