Bis(substituted methyl)-methyl-isoquinoline derivatives and pharmaceutical compositions containing them
US4654351A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 1984 |
| Grant date | Mar 31, 1987 |
| Priority date | — |
| Expiry date | Oct 25, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new bis(substituted methyl)-methyl-isoquinoline derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, PA1 R.sup.3 is hydrogen, aralkyl having from 1 to 4 carbon atoms in the alkyl moiety or a ##STR2## group, in which R.sup.4 is alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl or --NH--phenyl, PA2 X is oxygen or sulfur, PA1 R.sup.7 is hydroxyl, halogen or an ##STR3## group, R.sup.8 is halogen, alkoxy from 1 to 4 carbon atoms or an ##STR4## group, in which X has the same meaning as defined above, and PA2 R.sup.9 independently from R.sup.4 may have the same meanings as defined for R.sup.4, or is an --NH(C.sub.1-4 -alkyl) or C.sub.3-6 -cycloalkyl group, and salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds and pharmaceutical compositions containing them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.