Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen
US4654419A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 8, 1984 |
| Grant date | Mar 31, 1987 |
| Priority date | — |
| Expiry date | Aug 8, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/224
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antigens, immunogens, inocula, antibodies, diagnostic methods and systems relating to Epstein-Barr virus nuclear antigen (EBNA) are disclosed. Each of the compounds, compositions, methods or systems contains a synthetic, random copolymer polypeptide having about 6 to about 40 residues, or an antibody containing site that immunoreacts with such a polypeptide. The polypeptide includes the five amino acid residue sequence -Gly-R.sup.1 -Gly-R.sup.2 -Gly-, wherein R.sup.1 and R.sup.2 are the same or different amino acid residues selected from the group consisting of Ala, Asn, Arg, Gly, Leu, Pro, Ser, and Thr, with the provision that R.sup.1 and R.sup.2 are not both Gly. The polypeptide contains at least 25 mole percent Gly residues, and when linked to a carrier and introduced in an effective amount into a mammalian host is capable of inducing production of antibodies that immunoreact with EBNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.