Surface-modified electrode and its use in a bioelectrochemical process
US4655885A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 10, 1986 |
| Grant date | Apr 7, 1987 |
| Priority date | — |
| Expiry date | Jan 10, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/003
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In a bioelectrochemical process in which the electrons are transferred directly, without use of a mediator, such as a redox dye or cofactor, between an electrode and an electroactive biological material, such as an enzyme or a protein, in either direction, rapid electron transfer has previously been achieved between an electrode and the positively charged protein horse-heart cytochrome c by adding a surface-modifier such as 4,4'-bipyridyl or a derivative thereof. It has now been found possible to promote electron transfer to either a positively or a negatively charged protein using the same surface-modifier for either job, namely a compound of formula ##STR1## wherein: the pyridine ring shown is substituted in the 2-, 3- or 4-position by the (methylene)hydrazinecarbothioamide group shown; R.sup.1 represents hydrogen atom(s) or one or two methyl or ethyl groups in the 2-,3- or 4-position (when the said position is not substituted by the (methylene)hydrazinecarbothioamide group shown); PA1 R.sup.2 represents a hydrogen atom or a methyl group; PA1 R.sup.3 represents a hydrogen atom or a methyl group; and PA1 R.sup.4 represents a hydrogen atom or a methyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.