Novel process for the preparation of steroidal esters
US4655971A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 16, 1984 |
| Grant date | Apr 7, 1987 |
| Priority date | — |
| Expiry date | Aug 16, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J7/0085
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of corticosteriod esters of the formula ##STR1## in which ---- signifies that a double bond can be present; PA1 X is hydrogen, chlorine or fluorine; PA1 R.sub.1 is hydrogen, fluorine, chlorine or methyl, which may be either .alpha. or .beta.; PA1 R.sub.2 is halogen, oxo or hydroxyl; PA1 or R.sub.3 is hydrogen, .alpha.-methyl or .beta.-methyl; PA1 or R.sub.2 and X jointly form an epoxide group; PA1 R.sub.4 is an acyl group of the formula RCO, in which R is one of the following PA2 (i) an alkyl group containing 1 to 16 carbon atoms, whether straight-chained, branched or cyclic; PA2 (ii) an aralkyl group of 7 to 8 carbon atoms; PA2 (iii) a phenyl group; PA1 R.sub.5 is hydroxyl or R.sub.6 ; where PA1 R.sub.6 is hydrogen, one or two halogen atom substituents or OR.sub.7, where R.sub.7 is an acyl group of the formula R'CO in which R', which can be identical or different to R in the same molecule, is one of the following: PA2 (i) an alkyl group of 1 to 16 carbon atoms, whether straight-chained, branched or cyclic; PA2 (ii) an aralkyl group of 7 to 8 carbon atoms; or PA2 (iii) a phenyl group. which comprises esterifying a compound of the formula ##STR2## where…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.