Patent · US Expired

Process for the preparation of pentapeptides having an action on the immune system and intermediate products for this process

US4658016A · kind A · utility

2Cited by

2References

5Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Wolfgang Konig · Hofheim, DE
Rolf Geiger · Frankfurt am Main, DE
Rainer Obermeier
Hubert Mullner · Kelkheim, DE

Key dates

Filing date	Jun 7, 1985
Grant date	Apr 14, 1987
Priority date	—
Expiry date	Jun 7, 2005

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of peptides of the general formula EQU Arg--Lys--S--Val--Y in which S denotes glutamic acid or .alpha.-aminoadipic acid and Y denotes tyrosine or tryptophan or esters or amides thereof, which comprises subjecting tetrapeptides of the formula EQU Z--Arg(Z'.sub.2)--Lys(Z')--S--(Bzl)--Val--OH in which Z' represents a protective group of the benzyl type, to a condensation reaction with corresponding tyrosine esters or amides or tryptophan esters or amides and removing the protective groups by hydrogenation. The invention furthermore relates to tetrapeptides as intermediate products of this process.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.