6-phenethylaminoalkyl-furo-(3,4-c)-pyridine derivatives and therapeutic compositions containing the same

US4659719A · kind A · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventor

• Andre Esanu · Paris, FR

Key dates

• Filing date: Oct 21, 1985
• Grant date: Apr 21, 1987
• Expiry date: Oct 21, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to new 1,3-dihydro-6-[1-cyano-1-isopropyl-N-phenethyl-N-methyl-.omega.-aminoalkyl ]-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula ##STR1## wherein each of A.sub.1 and A.sub.2 independently represents various substituents and to pharmaceutically acceptable salts of said derivatives, to a process for the preparation of the same, comprising reacting, in stoichiometric proportions, at 15.degree.-65.degree. C., in dimethylsulphoxide, a 6-(1-cyano-2-methyl-propyl)-7-hydroxy-furo-(3,4-c)-pyridine derivative with the appropriate N-methyl-N-phenethyl-.omega.-aminoalkyl choride and, finally, to a therapeutic composition of matter comprising as an essential ingredient therein any of said compounds in an amount effective to act as a calcium antagonist or a serotonin antagonist together with an appropriate diluent or carrier.