Lipoxygenase inhibiting 1-arylalkyl-, 1-arylthio-, and 1-aryloxypyrazole-4,5-diones

US4659732A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hartmut Stegelmeier · Hilden, DE
• Volker-Bernd Fiedler · Leverkusen, DE
• Mithat Mardin · Wuppertal, DE
• Dieter Mayer · Werne, DE
• Elisabeth Perzborn · Wuppertal, DE
• Friedel Seuter

Key dates

• Filing date: Aug 27, 1985
• Grant date: Apr 21, 1987
• Expiry date: Aug 27, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Combating diseases of the respiratory tract, inflammations, rheumatism, thromboembolic diseases, ischaemias and infarcts, cardiac arrhythmias and arteriosclerosis with pyrazolediones of the formula ##STR1## wherein R represents an aryl or heteroaryl radical which has 6 to 12 C atoms and optionally contains 1 to 3 identical or different substituents from the group comprising halogen, trifluoromethyl, alkyl, alkenyl, alkoxy, alkylamino, cyano, trifluoromethoxy, nitro, hydroxyl, SO.sub.n -alkyl (n=0 to 2) or SO.sub.n -trifluoromethyl ) n=0 to 2), alkyl, alkenyl and alkoxy each having up to 4 C atoms, PA1 R.sup.1 represents hydrogen or a hydrocarbon radical which has 1 to 18 C atoms and optionally contains a hydroxyl, ether, ester or carboxyl group and optionally contains 1 to 3 halogen atoms, and X represents one of the groups --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --, --S--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 -- or ##STR2## the oxygen or sulphur atom being bonded to the radical R.