Support for solid-phase oligonucleotide synthesis
US4659774A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1985 |
| Grant date | Apr 21, 1987 |
| Priority date | — |
| Expiry date | Nov 1, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a support for oligonucleotide synthesis and more particularly to a necleoside-linker/polymer support composite having the general formula EQU P'--S' wherein P' is a polymer support which bears oxirane, aziridine or episulfide groups or which contains good leaving groups for nucleophilic displacement; and S' is a nucleoside-linker having the general formula EQU W--(CH.sub.2).sub.a --X--(CH.sub.2).sub.b --Y--(CH.sub.2).sub.c --Z EQU wherein W and Z each independently comprise a nucleophile; X and Y which, independently may or may not be present, comprise groups of high hydrophilicity; and a, b, c are integers from 0 to 9, wherein a plus b plus c exceeds 6.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.