Process for the preparation of fluoromethyl-quinoline derivatives
US4659834A · kind A · utility
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4Claims
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Key dates
| Filing date | Dec 5, 1983 |
| Grant date | Apr 21, 1987 |
| Priority date | — |
| Expiry date | Dec 5, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P33/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process is disclosed for preparing a compound of the Formula (I) ##STR1## wherein R.sup.2 is trifluoromethyl or chloro; PA1 R.sup.3 is hydrogen or chloro; and PA1 X is halogen; wherein a compound of the Formula (II) ##STR2## wherein R.sup.5 is --CFCl.sub.2, --CF.sub.2 Cl, or --CCl.sub.3 ; and PA1 R.sup.6 is chloro or trichloromethyl; is fluoroinated either with a mixture of antimony (III) fluoride and antimony (V) chloride or bromide; or with antimony (V) fluoride; or with antimony (V) chloride and hydrogen fluoride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.