Coupling agents for radiolabeled antibody fragments
US4659839A · kind A · utility
241Cited by
2References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 10, 1984 |
| Grant date | Apr 21, 1987 |
| Priority date | — |
| Expiry date | Oct 10, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bifunctional coupling agent for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.