Macromolecular coordination compound containing platinum with antitumor activity in rodents
US4659849A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1985 |
| Grant date | Apr 21, 1987 |
| Priority date | — |
| Expiry date | Nov 8, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G79/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A macromolecular compound with antitumor activity in which hydroxy groups in side chains of a polymer have the character of primary, secondary or tertiary alcohols and are completely or in part esterified with carboxyl in the position C4 of 1,2,4-tricarboxybenzene, whereas the carboxyls in positions C1 and C2 bind an atom of platinum with coordination bonded amino ligands. A method for producing the macromolecular compound consists in acylation of the polymer carrying alcohol groups with chloride anhydride of trimellitic acid of the formula II, ##STR1## hydrolyzing the anhydride in the subsequent step, and bonding an atom of bivalent platinum carrying an amino ligand to the formed vicinal carboxylic groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.