Active compound release systems

US4661104A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Miklos von Bittera · Leverkusen, DE
• Rolf-Volker Meyer · Krefeld, DE
• Rolf Dhein · Krefeld, DE

Key dates

• Filing date: Dec 14, 1984
• Grant date: Apr 28, 1987
• Expiry date: Dec 14, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/24479
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In a therapeutic system such as a plaster for administration of an active compound through the skin and comprising a covering layer which is essentially impermeable to the active compound, an active compound reservoir layer and a protective layer which can be pulled off and which is essentially impermeable to the active compound, the improvement wherein the reservoir layer contain about 1-30% of active compound in an elastomer mixture comprising a predominantly amorphous olefinic (co)polymer with a glass transition temperature of <20.degree. C., mixed with from 0 up to about 50% by weight of a polyisobutylene, polybutadiene oil and/or paraffin oil, and a tackifying resin. Thereby the active compound can be released in regulated relatively large quantity over a prolonged period of time.