Patent · US Expired

CL-1577-B.sub.4 compound, its production and use

US4661353A · kind A · utility

8Cited by

1References

1Claims

0Family size

Assignee

WARNER-LAMBERT COMPANY LLC · US

Inventors

John H. Wilton · Ann Arbor, US
Gerard C. Hokanson · Ann Arbor, US
James C. French · Ann Arbor, US

Key dates

Filing date	Dec 4, 1985
Grant date	Apr 28, 1987
Priority date	—
Expiry date	Dec 4, 2005

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12R2001/01
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound of CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions. CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line. A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.