Preparation of veratryl cyanide

US4661610A · kind A · utility

Assignee

• BASF SE

Inventors

• Josef Muller · Lakewood, US
• Walter-Wielant Wiersdorff · Mutterstadt, DE
• Wolfram Burst · Mannheim, DE
• Heinz Dralle · Minden, DE
• Ernst Schaffner
• Rolf Steinkamp · Minden, DE

Key dates

• Filing date: Jul 22, 1986
• Grant date: Apr 28, 1987
• Expiry date: Jul 22, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C255/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Veratryl cyanide is prepared by chloromethylating veratrol in solution in toluene and then reacting the resulting veratryl chloride with from 1 to 5 moles of an alkali metal cyanide, by a process in which the toluene from the chloromethylation is not removed for the reaction with cyanide, and from 3 to 25% by weight, based on veratryl chloride, of water, from 5 to 50% by weight, based on toluene, of a ketone of 3 to 6 carbon atoms and from 0.1 to 10% by weight, based on veratryl chloride, of a phase transfer catalyst are added before the reaction with cyanide.