Novel peptide hormones with calcitonin-like activity

US4663309A · kind A · utility

Assignee

• University Patents, Inc. · US

Inventors

• Emil T. Kaiser · New York, US
• Gregory R. Moe · Alameda, US

Key dates

• Filing date: Feb 27, 1985
• Grant date: May 5, 1987
• Expiry date: Feb 27, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula: ##STR1## wherein R.sub.1 is a moiety selected from the group consisting of ##STR2## R.sub.2 -R.sub.22 are amino acid moieties wherein R.sub.2 is an optional moiety which when present is selected from the group consisting of Ser and Gly, PA1 R.sub.8 is Leu or Val, PA1 R.sub.10 is Gln, Lys, or Gly, PA1 R.sub.11, R.sub.14, and R.sub.20 are each independently selected from the group consisting of Gln and Lys, PA1 R.sub.12 is Leu or Trp, PA1 R.sub.13 is Gln or Ser, PA1 R.sub.17 is Gln or His, PA1 R.sub.19 is Leu or Cys, PA1 R.sub.21 is Gln or Thr, PA1 R.sub.22 is an optional moiety which when present is selected from the group consisting of Leu and Tyr; PA0 R.sub.24 -R.sub.31 comprise a series of eight amino acids each independently selected from the group consisting of Gly, Ser, Thr, Cys, Tyr, Asn, Gln, Asp, Glu, Lys, Arg, and His, with the proviso that not more than one of said eight amino acids may be selected from the group consisting of Asp, Glu, Lys, Arg, and His, and with the proviso that no four or more of said eight amino acids will spontaneously form helical, .beta.-sheet, or .beta.-turn conformations; with the further proviso that when R.sub.19 is Cy…