Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor

US4663344A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Philippe L. Durette · New Providence, US
• Bruce E. Witzel · Westfield, US
• Kathleen M. Rupprecht · Cranford, US
• Allan N. Tischler · Westfield, US
• Timothy Francis Gallagher · Collegeville, US

Key dates

• Filing date: Mar 11, 1985
• Grant date: May 5, 1987
• Expiry date: Mar 11, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of 2-(2-carboxy-phenylthio)-.alpha.-substituted acetic acids. These compounds are found to be useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory diseases and other prostaglandin and/or leukotriene mediated diseases.