Use of etilefrin and etilefrin pivalate in the long term treatment of circulatory disorders not due to hypotonia

US4663354A · kind A · utility

Assignee

• Klinge Pharma GmbH · DE

Inventors

• Alois Niederhauser · Neukirchen am Teisenberg, DE
• Klaus Seibel · Gräfelfing, DE

Key dates

• Filing date: Apr 19, 1985
• Grant date: May 5, 1987
• Expiry date: Apr 19, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use of etilefrin or etilefrin pivalate in the long term treatment of circulatory disorders not due to hypotonia, such as for example peripheral arterial stenoses, leads surprisingly to a continuous stable rise in systolic blood pressure and blood pressure amplitude and an improved cardiac output, without affecting the diastolic blood pressure or the cardiac frequency. The pharmaceutical effect is enhanced by using etilefrin in combination with an extract of horse chestnut seeds in a long term treatment.