N.sup.2 (phenyl substituted) deoxy guanosine containing compounds
US4663446A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 27, 1983 |
| Grant date | May 5, 1987 |
| Priority date | — |
| Expiry date | Jun 27, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New purine compounds having the formula: ##STR1## Y and Y'=H, ##STR2## X=H, alkyl, halo; ##STR3## A=O, S, NH.sub.2 are provided. These compounds are useful in treating patients having cancer, since they are potent and selective inhibitors of replicative DNA synthesis in mammalian cells since they inhibit DNA polymerase .alpha.. New purine compounds also are provided having the formula: ##STR4## wherein Y, A, Z are as defined above, X'=C.sub.2 H.sub.5 Y"=--CH.sub.3 or ##STR5## These compounds are useful to prevent bacterial growth since they are potent inhibitors of DNA polymerase III. New Purine compounds also are provided having the formula: ##STR6## wherein Z' is H, OH or CH.sub.2 OH, PA1 A' is O of CH.sub.2 PA1 X"=H, alkyl, halo PA1 E=n-butyl, alkyl, halo, H PA1 G= ##STR7##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.