Peptide derivatives, the preparation and their use as elastase inhibitors
US4665053A · kind A · utility
6Cited by
2References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 1984 |
| Grant date | May 12, 1987 |
| Priority date | — |
| Expiry date | May 14, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0806
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Lipopeptides of the formula, R--X--(P.sub.1).sub.x -(L--Ala--L--Ala--P.sub.2 --A wherein x is 0 or 1, R is the acyl residue of a hydrophobic carboxylic acid, P.sub.2 is, for instance, L--Ala, L--Val, L--Pro--L--Ala or L--Pro--L--Val, P.sub.1 is a residue of an amino acid or an oligopeptide formed from 2-8 amino acids, X represent a divalent group or a direct covalent bond and A represents the C-terminal portion (modified or not) of --(P.sub.1).sub.x --(Ala--Ala--P.sub.2). These lipopeptides can be used as elastase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.