Peptide antagonists of neurokinin B
US4665157A · kind A · utility
9Cited by
2References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 30, 1985 |
| Grant date | May 12, 1987 |
| Priority date | — |
| Expiry date | Sep 30, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptides are of the following formula (I): EQU A.sup.1 -D-Pro.sup.2 -His.sup.3 -D.sup.4 -Phe.sup.5 -D-Trp.sup.6 -Val.sup.7 -D-Trp.sup.8 -Leu.sup.9 -Nle.sup.10 -NH.sub.2 (I) wherein A.sup.1 and D.sup.4 are Asp or D-Asp amino acids. Also described is an HPLC separation method using piperidine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.