2-vinylpenams and process
US4666835A · kind A · utility
5Cited by
3References
14Claims
0Family size
Inventor
Key dates
| Filing date | Apr 29, 1986 |
| Grant date | May 19, 1987 |
| Priority date | — |
| Expiry date | Apr 29, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/75
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
6.beta.-(L-.alpha.-Aminoadipoyl)-2.alpha.-vinyl-2.beta.-methylpenam-3-carbo xylic acid is provided in an enzymatic process converting .delta.-(L-.alpha.-aminoadipoyl)-L-cysteinyl-D-.gamma.,.delta.-didehydrois oleucine with isopenicillin N synthetase. The 2.alpha.-vinylpenam product is converted by known methods to the 6.beta.-amino-2.alpha.-vinyl-2.beta.-methylpenam-3-carboxylic acid nucleus and the latter is N-acylated to provide corresponding 6.beta.-acylaminopenams.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.