Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
US4666884A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 10, 1984 |
| Grant date | May 19, 1987 |
| Priority date | — |
| Expiry date | Apr 10, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting von Willebrand factor binding to human platelets induced with thrombin, ADP, or other stimuli has been developed. The administration of the small molecular weight peptide or the synthetic inhibitory molecule of the invention significantly inhibits thrombin or ADP-modified human platelets binding of von Willebrand factor, a plasma protein necessary for platelet interaction with blood vessels. The method of the invention is useful for inhibiting the formation of hemostatic platelet plugs and the initiation of thrombotic lesions. The blockage caused by hemostatic platelet plugs and the damage caused by thrombotic lesions are major factors in heart disease and stroke. The invention also includes a method of inducing the interaction of platelets with blood vessels by administration of a synthetic platelet reactive molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.