Novel peptide derivatives

US4666886A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Gerhard Baschang · Bettingen, CH
• Albert Hartmann · Grenzach, DE
• Oskar Wacker · Basel, CH

Key dates

• Filing date: Jul 17, 1985
• Grant date: May 19, 1987
• Expiry date: Jul 17, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to lipopeptides of the formula I, ##STR1## in which each of R.sub.a.sup.1 and R.sub.b.sup.1, independently of the other, represents an aliphatic or cycloaliphatic-aliphatic hydrocarbon radical having from 7 to 21 carbon atoms that is optionally substituted by oxygen functions, or PA0 one of the radicals R.sub.a.sup.1 --CO-- and R.sub.b.sup.1 --CO-- represents hydrogen and the other of the radicals R.sub.a.sup.1 --CO-- and R.sub.b.sup.1 --CO-- represents an acyl radical, wherein R.sub.a.sup.1 and R.sub.b.sup.1 have the meanings given above, PA0 R.sup.2 represents an aliphatic or cycloaliphatic-aliphatic hydrocarbon radical having from 1 to 21 carbon atoms that is optionally substituted by oxygen functions, PA0 n=0 or 1, PA0 As.degree. represents a radical of the formula --O--Kw--CO-- or --NH--Kw--CO-- wherein Kw represents an aliphatic hydrocarbon radical having a maximum of 12 carbon atoms, PA0 As.sup.1 represents a D- or L-.alpha.-amino acid, PA0 each of Z.sup.1 and Z.sup.2, independently of the other, represents hydroxy or the N-terminal radical of a D- or L-.alpha.-aminocarboxylic acid, of an amino-lower alkanesulphonic acid or of a peptide having a maximum…