Pyrrolobenzimidazoles for treating heart or circulatory diseases

US4666923A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Jens-Peter Holck · Mannheim, DE
• Alfred Mertens · Schriesheim, DE
• Wolfgang Kampe
• Bernd Muller-Beckmann · Bamberg, DE
• Gisbert Sponer · Hemsbach, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: May 7, 1985
• Grant date: May 19, 1987
• Expiry date: May 7, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions thereof for the treatment of coronary insufficiencies, cardiac failure, blood circulatory disturbances and occlusive diseases. The new pyrrolobenzimidazoles are of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, alkenyl or cycloalkyl, R.sub.2 is hydrogen, alkyl, alkenyl, cyano or a substituted carbonyl or R.sub.1 and R.sub.2 together represent cycloalkylene or form alkylidene or cycloalkylidene, X is a valency bond, C.sub.1 -C.sub.4 alkylene or vinylene, T is oxygen or sulphur and Py is pyridyl or substituted pyridyl and including the tautomers thereof and the physiologically acceptable salts thereof.