Formamidine derivatives and pharmaceutical use

US4666932A · kind A · utility

Assignee

• Istituto de Angeli S.p.A. · IT

Inventors

• Enzo Cereda · Novi Ligure, IT
• Giuseppe Bietti · Milano, IT
• Arturo Donetti · Milano, IT
• Piero Del Soldato · Monza, IT
• Antonio Giachetti · Marsala, IT
• Ferdinando Pagani · Verano Brianza, IT

Key dates

• Filing date: Jul 2, 1985
• Grant date: May 19, 1987
• Expiry date: Jul 2, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R is hydrogen or methyl; PA0 R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, dimethyldioxolylmethyl, hydroxymethyldioxolylmethyl, hydroxy(alkyl of 1 to 6 carbon atoms), mono- or di-(alkoxy of 1 to 6 carbon atoms)(alkyl of 1 to 6 carbon atoms), (alkyl of 1 to 6 carbon atoms)thio- (alkyl of 1 to 6 carbon atoms), (alkoxy of 1 to 6 carbon atoms)(alkyl of 1 to 6 carbon atoms)thio-(alkyl of 1 to 6 carbon atoms), cyano(alkyl of 1 to 6 carbon atoms), di-lower alkyl-amino(alkyl of 1 to 6 carbon atoms), alkenyl, alkynyl, or cycloalkyl; PA0 R.sub.2 and R.sub.3 are each independently hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halogen; and PA0 Z is imidazol-2-yl or imidazol-4-yl; provided however that, when R.sub.1 is straight or branched alkyl, alkenyl, alkynyl, cycloalkyl or cyano and R, R.sub.2 and R.sub.3 are hydrogen, Z is other than imidazol-4-yl; tautomers thereof and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiulcerogenics and gastric acid secretion inhibitors.